Trazodone official prescribing information for healthcare professionals. Includes: indications, dosage, adverse reactions, pharmacology and more. Trazodone is used to treat depression. Trazodone is in a class of medications called serotonin modulators. It works by increasing the amount of serotonin, a natural substance in the brain that helps maintain mental balance. Trazodone is an antidepressant medicine. It affects chemicals in the brain that may be unbalanced in people with depression. Trazodone is used to treat major depressive disorder. Find patient medical information for Trazodone Oral on WebMD including its uses, side effects and safety, interactions, pictures, warnings and user ratings. Description Trazodone acts to change the balance of naturally occurring chemicals in the brain that regulate the transmission of nerve impulses between cells. Trazodone, sold under many brand names, is an antidepressant medication. It is used to treat major depressive disorder, anxiety disorders, and, with other medications, alcohol dependence. It is taken by mouth. Common side effects of trazodone include lightheadedness, dry mouth, and drowsiness. Rare problems (reported in less than 1 percent of people) include numbness, increased salivation, and feelings of internal jitteriness. Trazodone (Desyrel, Trialodine) is an inexpensive drug used to treat depression. This drug is more popular than comparable drugs. It is available in multiple generic and brand versions. Trazodone (Desyrel) is drug is used for the treatment of depression, panic attacks, cocaine withdrawal, and aggressive behavior. Trazodone side effects include headaches, inability to ejaculate, constipation, blurred vision, and fatigue. Dosage for trazodone depends on what conditions the patient is being treated. Click for more about trazodone. Trazodone is approved by the FDA as a prescription drug used for the medical treatment of depression. Learn about side effects, drug interactions, dosages, warnings, and more.